Pyoderma gangrenosum associated with alitretinoin therapy.

PG: pyoderma gangrenosum INTRODUCTION Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition, the etiology of which is poorly understood but is thought to be related to improper neutrophil function and chemotaxis. PG is a clinical diagnosis that requires exclusion of other ulcerative and inflammatory cutaneous disorders. A rare side effect of isotretinoin is the development of PG. We report the first case, to our knowledge, of PG associated with alitretinoin therapy (Appendix).